Chance of a Lifetime was a competitive talent show which aired on ABC in 1952 – 1953 and 1955 – 1956 and on DuMont 1953 – 1955.

Dennis James was the host of the ABC version which ended on August 20th, 1953, and John Reed King was the host of the DuMont version, which ran from September 11th, 1953 to June 17th, 1955.  ABC then brought the show back from July 3rd, 1955 to June 23rd, 1956.  In 1954, comedian Jonathan Winters made his TV debut on the DuMont version of the show.